Questions from the Clinic:
Is adjuvant ozone (O 3 ) therapy effective in minimizing chemo-radiotherapy- induced toxicity? Does O 3 have any other clinical benefits that are currently under-appreciated in the oncology setting?
I. Historical Context
Ozone, or O3, is a relatively unstable allotrope of oxygen found in trace quantities throughout the Earth’s atmosphere. Concentrated primarily in the stratosphere, O3 shields life on Earth by absorbing ultraviolet radiation from the Sun’s rays.(1) Since the 1980s, conservation efforts have largely succeeded in preserving this protective atmospheric layer by curbing the use of industrial chloroflurocarbons, or CFCs.(2) That said, O3 has been known to humanity since the mid-19th century, when it was discovered by Christian Schonbein in a German lab. Soon after its discovery, O3 gradually found applications